Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice.

Zhang, Kexiong; Wang, Lihui; Hong, Xiaojing; Chen, Hao; Shi, Yao; Liu, Yingying; Liu, Jun; Liu, Jun-Ping

Zhang, Kexiong; Wang, Lihui; Hong, Xiaojing; Chen, Hao; Shi, Yao; Liu, Yingying; Liu, Jun; Liu, Jun-Ping.

Afiliación

Zhang K; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Wang L; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Hong X; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Chen H; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Shi Y; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Liu Y; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Liu J; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.
Liu JP; Institute of Ageing Research, Hangzhou Normal University School of Basic Medical Sciences, Hangzhou 311121, China.

Cells ; 10(11)2021 10 26.

Article en En | MEDLINE | ID: mdl-34831112

Asunto(s)

Células Epiteliales Alveolares/patología; Apoptosis; Diferenciación Celular; Senescencia Celular; Telomerasa/deficiencia; Proteína p53 Supresora de Tumor/metabolismo; Envejecimiento/patología; Animales; Caspasa 3/metabolismo; Inhibidor p16 de la Quinasa Dependiente de Ciclina/metabolismo; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Fibrosis Pulmonar Idiopática/patología; Inflamación/patología; Ratones Endogámicos C57BL; Ratones Noqueados; Subunidades de Proteína/metabolismo; ARN/metabolismo; Transducción de Señal; Células Madre/metabolismo; Telomerasa/metabolismo; Proteína p53 Supresora de Tumor/deficiencia

Palabras clave

apoptosis; differentiation; lung alveolar type 2 cells; p53; senescence; telomerase RNA component; telomere shortening

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Proteína p53 Supresora de Tumor / Senescencia Celular / Apoptosis / Telomerasa / Células Epiteliales Alveolares Idioma: En Revista: Cells Año: 2021 Tipo del documento: Article

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