Rewiring cell signalling pathways in pathogenic mtDNA mutations.
Trends Cell Biol
; 32(5): 391-405, 2022 05.
Article
en En
| MEDLINE
| ID: mdl-34836781
ABSTRACT
Mitochondria generate the energy to sustain cell viability and serve as a hub for cell signalling. Their own genome (mtDNA) encodes genes critical for oxidative phosphorylation. Mutations of mtDNA cause major disease and disability with a wide range of presentations and severity. We review here an emerging body of data suggesting that changes in cell metabolism and signalling pathways in response to the presence of mtDNA mutations play a key role in shaping disease presentation and progression. Understanding the impact of mtDNA mutations on cellular energy homeostasis and signalling pathways seems fundamental to identify novel therapeutic interventions with the potential to improve the prognosis for patients with primary mitochondrial disease.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
ADN Mitocondrial
/
Enfermedades Mitocondriales
Idioma:
En
Revista:
Trends Cell Biol
Año:
2022
Tipo del documento:
Article