Mismatch repair system deficiency is associated with chemoradiotherapy resistance in locally advanced rectal adenocarcinoma patients.

Ni, Kemin; Zhan, Yixiang; Liu, Zhaoce; Zhao, Xuan-Zhu; Wang, Wanting; Wang, Guihua; Zhang, Zili; Li, Guoxun; Zhang, Xipeng; Zhang, Chunze

Ni, Kemin; Zhan, Yixiang; Liu, Zhaoce; Zhao, Xuan-Zhu; Wang, Wanting; Wang, Guihua; Zhang, Zili; Li, Guoxun; Zhang, Xipeng; Zhang, Chunze.

Afiliación

Ni K; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.
Zhan Y; School of Medicine, Nankai University, Tianjin, China.
Liu Z; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.
Zhao XZ; School of Medicine, Nankai University, Tianjin, China.
Wang W; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.
Wang G; School of Medicine, Nankai University, Tianjin, China.
Zhang Z; Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, China.
Li G; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhang X; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhang C; GI Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.

J Surg Oncol ; 125(4): 692-702, 2022 Mar.

Article en En | MEDLINE | ID: mdl-34918842

Asunto(s)

Adenocarcinoma/patología; Biomarcadores de Tumor/metabolismo; Quimioradioterapia/métodos; Enzimas Reparadoras del ADN/metabolismo; Resistencia a Antineoplásicos; Tolerancia a Radiación; Neoplasias del Recto/patología; Adenocarcinoma/genética; Adenocarcinoma/metabolismo; Adenocarcinoma/terapia; Anciano; Biomarcadores de Tumor/genética; Reparación de la Incompatibilidad de ADN; Enzimas Reparadoras del ADN/genética; Femenino; Estudios de Seguimiento; Regulación Neoplásica de la Expresión Génica; Humanos; Masculino; Persona de Mediana Edad; Pronóstico; Neoplasias del Recto/genética; Neoplasias del Recto/metabolismo; Neoplasias del Recto/terapia; Estudios Retrospectivos; Tasa de Supervivencia

Palabras clave

chemoradiotherapy; dMMR; locally advanced rectal cancer; therapy resistance

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Tolerancia a Radiación / Neoplasias del Recto / Adenocarcinoma / Biomarcadores de Tumor / Resistencia a Antineoplásicos / Enzimas Reparadoras del ADN / Quimioradioterapia Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Surg Oncol Año: 2022 Tipo del documento: Article

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