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Acetyl-coenzyme A carboxylase beta gene polymorphism does not predict cardiovascular risk susceptibility in Chinese type 2 diabetic individuals.
Chan, Gary C W; Zhi, Helen; Hicks, Pamela J; Freedman, Barry I; Tang, Sydney C W.
Afiliación
  • Chan GCW; Division of Nephrology, Department of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Zhi H; Department of Biostatistics and Clinical Research Methodology Unit, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pok Fu Lam, Hong Kong.
  • Hicks PJ; Department of Biochemistry and Centers for Genomics and Personalized Medicine Research & Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
  • Freedman BI; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
  • Tang SCW; Division of Nephrology, Department of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Nephrology (Carlton) ; 27(5): 404-409, 2022 May.
Article en En | MEDLINE | ID: mdl-34939260
ABSTRACT

AIM:

Type 2 diabetes (T2D) is associated with significant cardiovascular (CV) morbidity and mortality. A single-nucleotide polymorphism (SNP) in the acetyl-coenzyme A carboxylase beta (ACACB) gene, rs2268388, reproducibly associates with diabetic nephropathy (DN). ACACB regulates fatty-acid oxidation. As such, we assessed whether ACACB SNP rs2268388 was associated with CV disease in Chinese individuals with T2D.

METHODS:

Chinese individuals with T2D were genotyped for SNP rs2268388. Baseline demographics were recorded and clinical data regarding coronary, carotid, and peripheral arterial disease and congestive heart failure were retrieved from electronic patient records. Statistical analyses were performed to detect associations between the rs2268388 T risk allele with CV outcomes in the cohort.

RESULTS:

A total of 596 Chinese individuals with T2D were genotyped. Their mean age was 66.8 ± 10.9 years at the time of data extraction. Genotyping revealed 59.7%, 33.2% and 7.1% of the study population were non-carriers, heterozygous and homozygous carriers of the rs2268388 T risk allele in ACACB. No statistically significant correlations of the risk allele were observed with CV outcomes.

CONCLUSION:

These results did not demonstrate association between rs2268388 SNP in ACACB with CV outcomes in Chinese T2D patients. The ACACB gene and its role in CV risk susceptibility, via alterations in fatty acid oxidation, remains an interesting postulate and studies with larger cohort sizes and in different ethnic groups remain warranted.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Acetil-CoA Carboxilasa / Enfermedades Cardiovasculares / Diabetes Mellitus Tipo 2 / Nefropatías Diabéticas Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies País/Región como asunto: Asia Idioma: En Revista: Nephrology (Carlton) Asunto de la revista: NEFROLOGIA Año: 2022 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Acetil-CoA Carboxilasa / Enfermedades Cardiovasculares / Diabetes Mellitus Tipo 2 / Nefropatías Diabéticas Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies País/Región como asunto: Asia Idioma: En Revista: Nephrology (Carlton) Asunto de la revista: NEFROLOGIA Año: 2022 Tipo del documento: Article