Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome through Modulation of Microbiome in the Gut-Lung Axis.

Sultan, Muthanna; Wilson, Kiesha; Abdulla, Osama A; Busbee, Philip Brandon; Hall, Alina; Carter, Taylor; Singh, Narendra; Chatterjee, Saurabh; Nagarkatti, Prakash; Nagarkatti, Mitzi

Sultan, Muthanna; Wilson, Kiesha; Abdulla, Osama A; Busbee, Philip Brandon; Hall, Alina; Carter, Taylor; Singh, Narendra; Chatterjee, Saurabh; Nagarkatti, Prakash; Nagarkatti, Mitzi.

Afiliación

Sultan M; Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Wilson K; Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Abdulla OA; Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Busbee PB; Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Hall A; Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Carter T; Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Singh N; Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Chatterjee S; Environmental Health and Disease Laboratory, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
Nagarkatti P; Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina School of Medicine, Columbia, SC 29209, USA.
Nagarkatti M; Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina School of Medicine, Columbia, SC 29209, USA.

Cells ; 10(12)2021 11 25.

Article en En | MEDLINE | ID: mdl-34943813

Asunto(s)

Ácidos Araquidónicos/uso terapéutico; Endocannabinoides/uso terapéutico; Microbioma Gastrointestinal; Tracto Gastrointestinal/patología; Pulmón/patología; Alcamidas Poliinsaturadas/uso terapéutico; Síndrome de Dificultad Respiratoria/tratamiento farmacológico; Síndrome de Dificultad Respiratoria/microbiología; Animales; Péptidos Antimicrobianos/metabolismo; Ácidos Araquidónicos/farmacología; Butiratos/metabolismo; Ciego/patología; Separación Celular; Colon/efectos de los fármacos; Colon/patología; Análisis Discriminante; Disbiosis/complicaciones; Disbiosis/microbiología; Endocannabinoides/farmacología; Enterotoxinas; Femenino; Tracto Gastrointestinal/efectos de los fármacos; Ganglios Linfáticos/efectos de los fármacos; Ganglios Linfáticos/patología; Activación de Linfocitos/efectos de los fármacos; Ratones Endogámicos C57BL; Neumonía/tratamiento farmacológico; Neumonía/microbiología; Alcamidas Poliinsaturadas/farmacología; Síndrome de Dificultad Respiratoria/complicaciones; Linfocitos T/efectos de los fármacos

Palabras clave

COVID-19; MiSeq sequencing; Staphylococcus enterotoxin B (SEB); acute respiratory distress syndrome (ARDS); anandamide (AEA); antimicrobial peptides (AMPs); gut-lung axis; microbiome; short-chain fatty acids (SCFAs); single-cell RNA (Sc-RNA)

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Síndrome de Dificultad Respiratoria / Ácidos Araquidónicos / Tracto Gastrointestinal / Endocannabinoides / Alcamidas Poliinsaturadas / Microbioma Gastrointestinal / Pulmón Idioma: En Revista: Cells Año: 2021 Tipo del documento: Article

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