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Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
Hurdiss, Daniel L; El Kazzi, Priscila; Bauer, Lisa; Papageorgiou, Nicolas; Ferron, François P; Donselaar, Tim; van Vliet, Arno L W; Shamorkina, Tatiana M; Snijder, Joost; Canard, Bruno; Decroly, Etienne; Brancale, Andrea; Zeev-Ben-Mordehai, Tzviya; Förster, Friedrich; van Kuppeveld, Frank J M; Coutard, Bruno.
Afiliación
  • Hurdiss DL; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, Netherlands.
  • El Kazzi P; Cryo-Electron Microscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.
  • Bauer L; Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.
  • Papageorgiou N; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, Netherlands.
  • Ferron FP; Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.
  • Donselaar T; Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.
  • van Vliet ALW; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, Netherlands.
  • Shamorkina TM; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, Netherlands.
  • Snijder J; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, Netherlands.
  • Canard B; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, Netherlands.
  • Decroly E; Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.
  • Brancale A; Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.
  • Zeev-Ben-Mordehai T; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK.
  • Förster F; Cryo-Electron Microscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.
  • van Kuppeveld FJM; Cryo-Electron Microscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands.
  • Coutard B; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, 3584CL Utrecht, Netherlands.
Sci Adv ; 8(1): eabj7615, 2022 Jan 07.
Article en En | MEDLINE | ID: mdl-34985963
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2022 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2022 Tipo del documento: Article