Type B lactic acidosis associated with diffuse large B-cell lymphoma and the Warburg effect.
J Int Med Res
; 50(1): 3000605211067749, 2022 Jan.
Article
en En
| MEDLINE
| ID: mdl-34986706
ABSTRACT
Type B lactic acidosis is a rare complication of non-tissue perfusion abnormalities caused by solid tumors or hematologic malignancies. Herein, we present the case of a 42-year-old man with type B lactic acidosis and hypoglycemia who was found to have a diffuse large B-cell lymphoma. The cause of lactic acidosis and/or hypoglycemia is thought to be the Warburg effect, which is when the metabolic rate of a rapidly growing malignant tumor is very high and dominated by glycolysis. Systemic damage from type B lactic acidosis can occur when the increased rate of glycolysis exceeds the normal muscle and liver lactic acid clearance rate. The Warburg effect is a rare but serious condition that needs to be recognized, not only in diffuse large B-cell lymphoma, but also in other malignancies. The prognosis of lactic acidosis in patients with malignant tumors is very poor. Currently, effective chemotherapy seems to be the only hope for survival.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Acidosis Láctica
/
Linfoma de Células B Grandes Difuso
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Hipoglucemia
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Int Med Res
Año:
2022
Tipo del documento:
Article