Nine-fold symmetry of centriole: The joint efforts of its core proteins.
Bioessays
; 44(3): e2100262, 2022 03.
Article
en En
| MEDLINE
| ID: mdl-34997615
ABSTRACT
The centriole is a widely conserved organelle required for the assembly of centrosomes, cilia, and flagella. Its striking feature - the nine-fold symmetrical structure, was discovered over 70 years ago by transmission electron microscopy, and since elaborated mostly by cryo-electron microscopy and super-resolution microscopy. Here, we review the discoveries that led to the current understanding of how the nine-fold symmetrical structure is built. We focus on the recent findings of the centriole structure in high resolution, its assembly pathways, and its nine-fold distributed components. We propose a model that the assembly of the nine-fold symmetrical centriole depends on the concerted efforts of its core proteins. Also see the video abstract here https//youtu.be/m4h_3II_WJo.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Centriolos
/
Centrosoma
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Bioessays
Asunto de la revista:
BIOLOGIA
/
BIOLOGIA MOLECULAR
Año:
2022
Tipo del documento:
Article