N6­methyladenosine upregulates miR­181d­5p in exosomes derived from cancer­associated fibroblasts to inhibit 5­FU sensitivity by targeting NCALD in colorectal cancer.

Pan, Shengli; Deng, Yingying; Fu, Jun; Zhang, Yuhao; Zhang, Zhijin; Qin, Xianju

N6methyladenosine upregulates miR181d5p in exosomes derived from cancerassociated fibroblasts to inhibit 5FU sensitivity by targeting NCALD in colorectal cancer.

Pan, Shengli; Deng, Yingying; Fu, Jun; Zhang, Yuhao; Zhang, Zhijin; Qin, Xianju.

Afiliación

Pan S; Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People Hospital, Jiangsu University, Shanghai 200232, P.R. China.
Deng Y; Department of Ophthalmology, Shanghai Eighth People Hospital, Jiangsu University, Shanghai 200232, P.R. China.
Fu J; Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People Hospital, Jiangsu University, Shanghai 200232, P.R. China.
Zhang Y; Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People Hospital, Jiangsu University, Shanghai 200232, P.R. China.
Zhang Z; Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People Hospital, Jiangsu University, Shanghai 200232, P.R. China.
Qin X; Division of Gastrointestinal Surgery, Department of General Surgery, Shanghai Eighth People Hospital, Jiangsu University, Shanghai 200232, P.R. China.

Int J Oncol ; 60(2)2022 02.

Article en En | MEDLINE | ID: mdl-35014676

Asunto(s)

Adenosina/análogos & derivados; Fluorouracilo/metabolismo; MicroARNs/metabolismo; Neurocalcina/efectos de los fármacos; Adenosina/genética; Adenosina/metabolismo; Fibroblastos Asociados al Cáncer/efectos de los fármacos; Fibroblastos Asociados al Cáncer/metabolismo; Línea Celular Tumoral; Proliferación Celular/genética; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/metabolismo; Humanos; MicroARNs/efectos de los fármacos; Neurocalcina/metabolismo; Regulación hacia Arriba/genética; Regulación hacia Arriba/inmunología

Palabras clave

cancerassociated fibroblast; chemosensitivity; colorectal cancer; exosome; microRNA

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Adenosina / MicroARNs / Neurocalcina / Fluorouracilo Tipo de estudio: Diagnostic_studies / Risk_factors_studies Idioma: En Revista: Int J Oncol Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article

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