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Comparison of Coinduction Adjuvants to Propofol in Healthy Cats Sedated With Dexmedetomidine.
Zavataro, A L; Bonatto, Ncm; Julião, G H; Costa, I M; Moreira, T F; Zamboni, Vag; Floriano, B P.
Afiliación
  • Zavataro AL; University Center of the Integrated Faculties of Ourinhos, São Paulo State, Brazil.
  • Bonatto N; University Center of the Integrated Faculties of Ourinhos, São Paulo State, Brazil.
  • Julião GH; Roque Quagliato Veterinary Teaching Hospital, University Center of the Integrated Faculties of Ourinhos, São Paulo State, Brazil.
  • Costa IM; Roque Quagliato Veterinary Teaching Hospital, University Center of the Integrated Faculties of Ourinhos, São Paulo State, Brazil.
  • Moreira TF; Roque Quagliato Veterinary Teaching Hospital, University Center of the Integrated Faculties of Ourinhos, São Paulo State, Brazil.
  • Zamboni V; Roque Quagliato Veterinary Teaching Hospital, University Center of the Integrated Faculties of Ourinhos, São Paulo State, Brazil.
  • Floriano BP; University Center of the Integrated Faculties of Ourinhos, São Paulo State, Brazil. Electronic address: biapflor@gmail.com.
Top Companion Anim Med ; 48: 100634, 2022.
Article en En | MEDLINE | ID: mdl-35045356
ABSTRACT
This study aimed to compare the effects of different coinduction agents on the duration and dose of propofol in healthy cats. Six cats aged 4.8 ± 1.0 years and weighing 4.4 ± 1.1 kg participated in 4 treatment groups of propofol combined with saline or control group (TC); ketamine 2 mg/kg (Tket); fentanyl 1 µg/kg (Tfen); or midazolam 0.3 mg/kg (Tmid). Twenty minutes following premedication with dexmedetomidine at 10 µg/kg, induction followed the same protocol in all groups, starting with a propofol bolus of 1 mg/kg over 1 minute followed by an adjuvant, then propofol again at 1 mg/kg/minute for orotracheal intubation. Variables recorded were (in minutes) time of extubation, time to return of palpebral reflex, eye recentralization, recovery of consciousness, quadrupedal position and total propofol dose used (mg/kg). A comparison between the 4 groups was performed by analysis of variance followed by Dunnett test under 5% significance. There was no significant difference in any of the times evaluated during anesthetic recovery between the groups. The propofol dose used to allow orotracheal intubation was significantly lower in all groups compared to TC (P < .05). Ketamine, midazolam, and fentanyl are indicated as suitable choices for coinduction with propofol in cats.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Propofol / Dexmedetomidina / Ketamina Tipo de estudio: Guideline Idioma: En Revista: Top Companion Anim Med Asunto de la revista: MEDICINA VETERINARIA Año: 2022 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Propofol / Dexmedetomidina / Ketamina Tipo de estudio: Guideline Idioma: En Revista: Top Companion Anim Med Asunto de la revista: MEDICINA VETERINARIA Año: 2022 Tipo del documento: Article