The impact of contact tracing and testing on controlling COVID-19 outbreak without lockdown in Hong Kong: An observational study.

ABSTRACT

BACKGROUND: Maintaining effective contact tracing to control COVID-19 is challenging. Rapid growth in the number of infected cases can overload tracing and testing capacity, resulting in failure to trace contacts and delays in confirming an infection until after symptom onset (confirmation delay), hence increasing transmissibility. A substantial outbreak in Hong Kong, which was suppressed with non-pharmaceutical interventions (NPIs), provided an opportunity to assess the impact of overloading contact tracing and of efforts to improve its efficiency. METHODS: Using epidemiological-link (epi-link) data, we calculated the probability and duration of confirmation delay for cases with and without an epi-link, among all 3,148 confirmed cases between 5 July and 15 August 2020. Logistic regression was performed to determine the relationship between the number of recently confirmed infections and the probability of confirmation delay for epi-linked (contact-traced) cases. We estimated the impact on this relationship of targeted testing of at-risk groups. FINDINGS: The probability and duration of confirmation delay were associated with the rise in daily case number during growth of the outbreak. The proportion with confirmation delay among contact-traced cases increased from about 60 % to nearly 85 % as the number of cases grew from 1 to 50 per day (p-value = 0.003). The subsequent introduction of testing services for at-risk groups substantially reduced the proportion and it did not approach 85 % again until the daily number of cases exceeded 125. This 2.5-fold improvement in capacity contributed crucially to suppression of the outbreak. INTERPRETATION: The number of recently confirmed infections is an indicator of the load on the contact-tracing system, the consequence of which can be assessed by the probability of confirmation delay. Measures to monitor and improve contact-tracing efficiency, alongside social distancing interventions, can enable outbreaks to be controlled without lockdown. FUNDING: City University of Hong Kong and Health and Medical Research Fund.