Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1ß-induced osteoarthritis by downregulating the MAPK and NF-&#954;B pathways.

Xu, Fang; Zhao, Liang-Jun; Liao, Ting; Li, Zhao-Cong; Wang, Lei-Lei; Lin, Pan-Yu; Jiang, Rui; Wei, Qing-Jun

Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1ß-induced osteoarthritis by downregulating the MAPK and NF-κB pathways.

Xu, Fang; Zhao, Liang-Jun; Liao, Ting; Li, Zhao-Cong; Wang, Lei-Lei; Lin, Pan-Yu; Jiang, Rui; Wei, Qing-Jun.

Afiliación

Xu F; Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Shuangyong Road No. 6, Nanning, 530021, China.
Zhao LJ; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, China.
Liao T; Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
Li ZC; Department of Endocrinology, Liuzhou Municipal Liutie Central Hospital, Feie Road No. 22, Liuzhou, 545007, China.
Wang LL; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, China.
Lin PY; Department of Toxicology, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, China.
Jiang R; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, China.
Wei QJ; Department of Toxicology, School of Public Health, Guangxi Medical University, Shuangyong Road No. 22, Nanning, 530021, Guangxi, China.

BMC Complement Med Ther ; 22(1): 25, 2022 Jan 27.

Article en En | MEDLINE | ID: mdl-35086536

Asunto(s)

Cartílago/efectos de los fármacos; Glucósidos/farmacología; Inflamación/metabolismo; Interleucina-1beta/metabolismo; Isoflavonas/farmacología; Proteínas Quinasas Activadas por Mitógenos/metabolismo; FN-kappa B/metabolismo; Osteoartritis; Animales; Antiinflamatorios/farmacología; Antiinflamatorios/uso terapéutico; Cartílago/citología; Cartílago/metabolismo; Cartílago/patología; Condrocitos/efectos de los fármacos; Condrocitos/metabolismo; Condrocitos/patología; Regulación hacia Abajo; Glucósidos/uso terapéutico; Inflamación/tratamiento farmacológico; Isoflavonas/uso terapéutico; Sistema de Señalización de MAP Quinasas; Masculino; Metaloproteinasa 13 de la Matriz/metabolismo; Osteoartritis/tratamiento farmacológico; Osteoartritis/metabolismo; Osteoartritis/patología; Fitoterapia; Extractos Vegetales/farmacología; Extractos Vegetales/uso terapéutico; Ratas Sprague-Dawley; Transducción de Señal; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Chondrocyte; Collagen II; Inflammation; MAPK; MMP-13; NF-κB; Ononin; Osteoarthritis

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Osteoartritis / Cartílago / FN-kappa B / Proteínas Quinasas Activadas por Mitógenos / Interleucina-1beta / Glucósidos / Inflamación / Isoflavonas Tipo de estudio: Prognostic_studies Idioma: En Revista: BMC Complement Med Ther Año: 2022 Tipo del documento: Article

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