A Novel Injectable Hydrogel Matrix Loaded With 90Y Microspheres for the Treatment of Solid Tumors.
Anticancer Res
; 42(2): 827-836, 2022 Feb.
Article
en En
| MEDLINE
| ID: mdl-35093880
ABSTRACT
BACKGROUND/AIM:
The need to concentrate the anti-tumoral activity of 90Y only to the targeted tumor, while minimizing its off-target effects, led to the development of an innovative device (BAT-90) composed of a hydrogel matrix and 90Y microspheres. MATERIALS ANDMETHODS:
This in vivo randomized study was planned to assess the efficacy, safety, and biodistribution of BAT-90 in 46 rabbits implanted with a VX2 tumor. The effects of BAT-90 were compared to those of 90Y microspheres and the hydrogel matrix.RESULTS:
BAT-90 localized effectively the 90Y radiation in the injection site, minimizing dispersion of the microspheres in the target and distant organs of the treated animals.CONCLUSION:
BAT-90 can be administered as an adjuvant treatment to clear surgical margins from any potential minimal residual disease, or as an alternative to other loco-regional treatments for non-resectable tumors.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Radioisótopos de Itrio
/
Hidrogeles
/
Microesferas
/
Antineoplásicos
Idioma:
En
Revista:
Anticancer Res
Año:
2022
Tipo del documento:
Article