Induction and Regulation of the Innate Immune Response in Helicobacter pylori Infection.
Cell Mol Gastroenterol Hepatol
; 13(5): 1347-1363, 2022.
Article
en En
| MEDLINE
| ID: mdl-35124288
ABSTRACT
Gastric cancer (GC) is the fifth most common cancer and the fourth most common cause of cancer-related death worldwide. The intestinal type of GC progresses from acute to chronic gastritis, multifocal atrophic gastritis, intestinal metaplasia, dysplasia, and carcinoma. Infection of the stomach by Helicobacter pylori, a Gram-negative bacterium that infects approximately 50% of the world's population, is the causal determinant that initiates the gastric inflammation and then disease progression. In this context, the induction of the innate immune response of gastric epithelial cells and myeloid cells by H. pylori effectors plays a critical role in the outcome of the infection. However, only 1% to 3% of infected patients develop gastric adenocarcinoma, emphasizing that other mechanisms regulate the localized non-specific response, including the gastric microbiota and genetic factors. This review summarizes studies describing the factors that induce and regulate the mucosal innate immune response during H. pylori infection.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
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Helicobacter pylori
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Infecciones por Helicobacter
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Gastritis Atrófica
Idioma:
En
Revista:
Cell Mol Gastroenterol Hepatol
Año:
2022
Tipo del documento:
Article