Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis.
Biomed Res Int
; 2022: 5239255, 2022.
Article
en En
| MEDLINE
| ID: mdl-35132377
ABSTRACT
Endothelial cells are heterogeneous, stemming from multiple organs, but there is still little known about the connection between the brain and kidney endothelial cells, especially in homeostasis. In this study, scRNA-seq results were obtained to compare genetic profiles and biological features of tissue-specific endothelial cells. On this basis, seven endothelial cell subpopulations were identified, two of which were upregulated genes in pathways related to stroke and/or depression, as characterized by neuroinflammation. This study revealed the similarities and distinctions between brain and kidney endothelial cells, providing baseline information needed to fully understand the relationship between renal diseases and neuroinflammation, such as stroke and depression.
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Base de datos:
MEDLINE
Asunto principal:
Encéfalo
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Células Epiteliales
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Transcriptoma
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Homeostasis
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Riñón
Idioma:
En
Revista:
Biomed Res Int
Año:
2022
Tipo del documento:
Article