Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications.

Lopez-Bertoni, Hernando; Johnson, Amanda; Rui, Yuan; Lal, Bachchu; Sall, Sophie; Malloy, Maureen; Coulter, Jonathan B; Lugo-Fagundo, Maria; Shudir, Sweta; Khela, Harmon; Caputo, Christopher; Green, Jordan J; Laterra, John

Lopez-Bertoni, Hernando; Johnson, Amanda; Rui, Yuan; Lal, Bachchu; Sall, Sophie; Malloy, Maureen; Coulter, Jonathan B; Lugo-Fagundo, Maria; Shudir, Sweta; Khela, Harmon; Caputo, Christopher; Green, Jordan J; Laterra, John.

Afiliación

Lopez-Bertoni H; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA. Lopezbertoni@kennedykrieger.org.
Johnson A; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Lopezbertoni@kennedykrieger.org.
Rui Y; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA.
Lal B; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sall S; Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Malloy M; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA.
Coulter JB; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lugo-Fagundo M; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA.
Shudir S; Bloomberg School of Public Health, Department of Environmental Health and Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Khela H; Bloomberg School of Public Health, Department of Environmental Health and Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Caputo C; The Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Green JJ; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA.
Laterra J; Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA.

Signal Transduct Target Ther ; 7(1): 37, 2022 02 09.

Article en En | MEDLINE | ID: mdl-35136034

Asunto(s)

Neoplasias Encefálicas/metabolismo; Metilación de ADN; ADN de Neoplasias/metabolismo; Proteínas de Unión al ADN/metabolismo; Dioxigenasas/metabolismo; Glioblastoma/metabolismo; Proteínas de Neoplasias/metabolismo; Células Madre Neoplásicas/metabolismo; Factores de Transcripción SOXB1/metabolismo; Animales; Neoplasias Encefálicas/genética; Línea Celular Tumoral; Citidina/análogos & derivados; Citidina/genética; Citidina/metabolismo; ADN de Neoplasias/genética; Proteínas de Unión al ADN/genética; Dioxigenasas/genética; Femenino; Glioblastoma/genética; Humanos; Ratones; Ratones Desnudos; Proteínas de Neoplasias/genética; Factores de Transcripción SOXB1/genética

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Neoplasias Encefálicas / ADN de Neoplasias / Glioblastoma / Metilación de ADN / Dioxigenasas / Proteínas de Unión al ADN / Factores de Transcripción SOXB1 / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies Idioma: En Revista: Signal Transduct Target Ther Año: 2022 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google