Larrea divaricata: anti-inflammatory and antioxidant effects of on macrophages and low density lipoproteins.
BMC Complement Med Ther
; 22(1): 84, 2022 Mar 23.
Article
en En
| MEDLINE
| ID: mdl-35321702
ABSTRACT
BACKGROUND:
The oxidized low density lipoprotein (ox-LDL) contributes to inflammation and oxidative stress through the activation of macrophages under hyperglycemia contributing to the development of diabetes mellitus and to atherosclerosis. Plants are a source of effective and innocuous antioxidants. Larrea divaricata Cav. (Zygophyllaceae) is used in Argentina folk medicine for its anti-inflammatory properties.METHODS:
The aim of this work was to study the antioxidant and anti-inflammatory effects of the aqueous extract (AE) of L. divaricata on macrophages under glucose stimulation and on human LDL and HDL particles under free radical generators.RESULTS:
AE reduced the lipid peroxidation (17%), nitric oxide (NO) (47-50%), tumor necrosis factor-α (TNF-α) (32%) and free radicals (50%) induced by glucose on macrophages. Also prevented HDL nitration (28%), thus preserving its function and structure and inhibited LDL oxidation. The effect on the nitrosative stress was mainly driven by nordihydroguaiaretic acid (NDGA).CONCLUSIONS:
These results suggest a potential usefulness of AE as an adjuvant phytotherapy in patients with diabetes mellitus and atherosclerosis.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Antiinflamatorios no Esteroideos
/
Larrea
/
Lipoproteínas LDL
/
Macrófagos
/
Antioxidantes
Idioma:
En
Revista:
BMC Complement Med Ther
Año:
2022
Tipo del documento:
Article