Hyperoside exerts osteoprotective effect on dexamethasone-induced osteoblasts by targeting NADPH Oxidase 4 (NOX4) to inhibit the reactive oxygen species (ROS) accumulation and activate c-Jun N-terminal kinase (JNK) pathway.

Fan, Siqi; Pan, Haida; Huang, Jiaxing; Lei, Zhiqiang; Liu, Jinfu

Fan, Siqi; Pan, Haida; Huang, Jiaxing; Lei, Zhiqiang; Liu, Jinfu.

Afiliación

Fan S; Department of Orthopedics and Traumatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China.
Pan H; Research Student Academy, Guangxi University of Traditional Chinese Medicine, Nanning, China.
Huang J; Yulin Orthopedics Hospital of Chinese and Western Medicine, Yulin, China.
Lei Z; Emergency Department, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China.
Liu J; Department of Orthopedics and Traumatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China.

Bioengineered ; 13(4): 8657-8666, 2022 04.

Article en En | MEDLINE | ID: mdl-35331079

Asunto(s)

Proteínas Quinasas JNK Activadas por Mitógenos; Osteogénesis; Apoptosis; Línea Celular; Dexametasona/metabolismo; Dexametasona/farmacología; Proteínas Quinasas JNK Activadas por Mitógenos/metabolismo; Proteínas Quinasas JNK Activadas por Mitógenos/farmacología; NADPH Oxidasa 4/genética; NADPH Oxidasa 4/metabolismo; NADPH Oxidasa 4/farmacología; Osteoblastos; Quercetina/análogos & derivados; Especies Reactivas de Oxígeno/metabolismo

Palabras clave

Hyperoside; NADPH oxidase 4; osteoblast; osteonecrosis of the femoral head

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Osteogénesis / Proteínas Quinasas JNK Activadas por Mitógenos Tipo de estudio: Prognostic_studies Idioma: En Revista: Bioengineered Año: 2022 Tipo del documento: Article

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