A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases.
Molecules
; 27(6)2022 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-35335258
ABSTRACT
Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Virus de la Encefalitis Transmitidos por Garrapatas
/
COVID-19
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2022
Tipo del documento:
Article