Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma <i>in situ</i>: A Case Report.

Mammary Paget Disease With Melanocytic Proliferation Mimicking Malignant Melanoma in situ: A Case Report.

Rao, Shijia; Wang, Alun; Liu, Wei; Yin, Hongling; Li, Ji; Tsang, Lemuel Shui-Lun; Wu, Yuhui; Shi, Wei.

Afiliación

Rao S; Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, China.
Wang A; Department of Pathology, Tulane University School of Medicine, New Orleans, LA, United States.
Liu W; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.
Yin H; Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.
Li J; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Tsang LS; College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, United States.
Wu Y; Department of Breast Surgery, Xiangya Hospital, Central South University, Changsha, China.
Shi W; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Front Med (Lausanne) ; 9: 839954, 2022.

Article en En | MEDLINE | ID: mdl-35386919

ABSTRACT

Several cases of pigmented mammary Paget's disease (PMPD) mimicking cutaneous malignant melanoma have been reported. In these cases, the tumor cells are colonized by melanocytes, particularly with the presence of a population of melanocytes staining for HMB-45 and S100. Here, we report a case of mammary Paget disease (MPD) which was misdiagnosed as melanoma in situ due to the interpretation of the staining of melanocytic markers S-100, Melan-A, and HMB-45. The tumor cells strongly expressed CK7 and GATA3, and a dual-labeling showed negative PHH3 labeling for the melanocytes. Pathologists need to be aware of the caveat of colonization of melanocytes in Paget disease.

Palabras clave

dermatology; mammary Paget disease; melanocytic proliferation; melanoma in situ; pathology