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New composition of tungsten has a broad range of antiviral activity.
Avagyan, Hranush; Mirzoyan, Anaida; Mirzoyan, Ferdinand; Izmailyan, Roza; Hakobyan, Sona; Voskanyan, Henry; Semerjyan, Zara; Avetisyan, Aida; Arzumanyan, Hranush; Karalova, Elena; Abroyan, Liana; Hakobyan, Lina; Bayramyan, Nane; Gevorgyan, Nazeli; Karalyan, Alexander; Karalyan, Zaven.
Afiliación
  • Avagyan H; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, Yerevan, Armenia.
  • Mirzoyan A; Experimental Laboratory Yerevan State Medical University, Yerevan, Armenia.
  • Mirzoyan F; Surb Grigor Lusavorich Medical Center, Yerevan, Armenia.
  • Izmailyan R; Institute of General and Inorganic Chemistry, NAS Armenia, Yerevan, Armenia.
  • Hakobyan S; Group of antiviral defense mechanisms, Institute of Molecular Biology of NAS RA, Yerevan, Armenia.
  • Voskanyan H; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, Yerevan, Armenia.
  • Semerjyan Z; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, Yerevan, Armenia.
  • Avetisyan A; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, Yerevan, Armenia.
  • Arzumanyan H; Experimental Laboratory Yerevan State Medical University, Yerevan, Armenia.
  • Karalova E; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, Yerevan, Armenia.
  • Abroyan L; Experimental Laboratory Yerevan State Medical University, Yerevan, Armenia.
  • Hakobyan L; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, Yerevan, Armenia.
  • Bayramyan N; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, Yerevan, Armenia.
  • Gevorgyan N; Experimental Laboratory Yerevan State Medical University, Yerevan, Armenia.
  • Karalyan A; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, Yerevan, Armenia.
  • Karalyan Z; Laboratory of Cell Biology and Virology, Institute of Molecular Biology of NAS RA, Yerevan, Armenia.
Antivir Chem Chemother ; 30: 20402066221090061, 2022.
Article en En | MEDLINE | ID: mdl-35392696
The water-based combination of two inorganic chemical compounds such as sodium tungstate dihydrate-Na2WO4 × 2H2O and Aluminum sulfate octadecahydrate-Al2 (SO4) 3 × 18H2O that we have conditionally named 'Vomifal' has a broad antiviral activity in various DNA and RNA viruses, including Human Herpes Virus (HHV), African Swine Fever Virus (ASFV), Vaccinia Virus (VV), Hepatitis C Virus (HCV), Foot and Mouth Disease Virus (FMDV), Influenza A virus (A/Aichi/2/68 (H3N2)). In vitro and In vivo assays in several tissue cultures as well as in laboratory animals, conformed 'Vomifal' has a very low toxicity and the antiviral properties partially are due to its ability to induce gamma-IFN. Based on the results obtained, we can assume the presence of at least two mechanisms of the antiviral action of the studied drug. First or early stage - an unknown mechanism, possibly related to the effect on cellular receptors. Second or late stage - main antiviral properties probably associated with an interferonogenic effect.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Virus de la Fiebre Aftosa / Virus de la Fiebre Porcina Africana Idioma: En Revista: Antivir Chem Chemother Asunto de la revista: QUIMICA / TERAPIA POR MEDICAMENTOS / VIROLOGIA Año: 2022 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Virus de la Fiebre Aftosa / Virus de la Fiebre Porcina Africana Idioma: En Revista: Antivir Chem Chemother Asunto de la revista: QUIMICA / TERAPIA POR MEDICAMENTOS / VIROLOGIA Año: 2022 Tipo del documento: Article