A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies.

Zimmermann, Astrid; Zenke, Frank T; Chiu, Li-Ya; Dahmen, Heike; Pehl, Ulrich; Fuchss, Thomas; Grombacher, Thomas; Blume, Beatrix; Vassilev, Lyubomir T; Blaukat, Andree

Zimmermann, Astrid; Zenke, Frank T; Chiu, Li-Ya; Dahmen, Heike; Pehl, Ulrich; Fuchss, Thomas; Grombacher, Thomas; Blume, Beatrix; Vassilev, Lyubomir T; Blaukat, Andree.

Afiliación

Zimmermann A; Translational Innovation Platform Oncology and Immuno-Oncology, The Healthcare Business of Merck KGaA, Darmstadt, Germany.
Zenke FT; Translational Innovation Platform Oncology and Immuno-Oncology, The Healthcare Business of Merck KGaA, Darmstadt, Germany.
Chiu LY; Translational Innovation Platform Oncology and Immuno-Oncology, EMD Serono, Billerica, Massachusetts.
Dahmen H; Translational Innovation Platform Oncology and Immuno-Oncology, The Healthcare Business of Merck KGaA, Darmstadt, Germany.
Pehl U; Discovery and Development Technologies, Cellular Pharmacology, The Healthcare Business of Merck KGaA, Darmstadt, Germany.
Fuchss T; Discovery and Development Technologies, Global Medicinal Chemistry, The Healthcare Business of Merck KGaA, Darmstadt, Germany.
Grombacher T; Translational Medicine, The Healthcare Business of Merck KGaA, Darmstadt, Germany.
Blume B; Discovery and Development Technologies, Cellular Pharmacology, The Healthcare Business of Merck KGaA, Darmstadt, Germany.
Vassilev LT; Translational Innovation Platform Oncology and Immuno-Oncology, EMD Serono, Billerica, Massachusetts.
Blaukat A; Translational Innovation Platform Oncology and Immuno-Oncology, The Healthcare Business of Merck KGaA, Darmstadt, Germany.

Mol Cancer Ther ; 21(6): 859-870, 2022 06 01.

Article en En | MEDLINE | ID: mdl-35405736

Asunto(s)

Ataxia Telangiectasia; Neoplasias; Animales; Ataxia Telangiectasia/genética; Proteínas de la Ataxia Telangiectasia Mutada; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo; ADN; Roturas del ADN de Doble Cadena; Reparación del ADN; Humanos; Ratones; Neoplasias/tratamiento farmacológico; Neoplasias/genética; Inhibidores de Proteínas Quinasas/farmacología

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ataxia Telangiectasia / Neoplasias Idioma: En Revista: Mol Cancer Ther Asunto de la revista: ANTINEOPLASICOS Año: 2022 Tipo del documento: Article

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