3C, chromosome conformation capture; 4C, chromosome conformation capture-on-chip; AH, alcohol-related hepatitis; ARLD, alcohol-related liver disease; ASH, alcohol-related steatohepatitis; ATAC, assay for transposase-accessible chromatin; Acetylation; Alcohol liver disease; BET, bromodomain and extraterminal motif; BETi, BET inhibitor; BRD, bromodomain; CCL2, C-C motif chemokine ligand 2; CTCF, CCCTC-binding factor; CXCL, C-X-C motif chemokine ligand; Chromatin architecture; Computational biology; DNA methylation; DNMT, DNA methyltransferase; E-P, enhancer-promoter; Epidrugs; Epigenetics; FKBP5, FK506-binding protein 5; HCC, hepatocellular carcinoma; HDAC, histone deacetylase; HIF1α, hypoxia inducible factor-1α; HMGB1, high-mobility group box protein 1; HNF4α, hepatocyte nuclear factor 4α; HSC, hepatic stellate cell; Hi-C, chromosome capture followed by high-throughput sequencing; Histones; IL, interleukin; LPS, lipopolysaccharide; MALAT1, metastasis-associated lung adenocarcinoma transcript 1; MECP2, methyl-CpG binding protein 2; NAFLD, non-alcohol-related fatty liver disease; PPARG, peroxisome proliferator activated receptor-γ; SAA, salvianolic acid A; SIRT, sirtuin; SREBPs, sterol regulatory element-binding proteins; Single cell epigenome; TAD, topologically associating domain; TEAD, TEA domain transcription factor; TLR, Toll-like receptor; TNF, tumour necrosis factor; YAP, Yes-associated protein; lncRNA, long non-coding RNA; miRNA, microRNA