Cryo-electron microscopy analysis of myosin at work and at rest.
Curr Opin Struct Biol
; 75: 102391, 2022 08.
Article
en En
| MEDLINE
| ID: mdl-35636003
ABSTRACT
Myosins are a superfamily of ATP-driven actin-dependent molecular motors that are responsible for diverse functions from muscle contraction to cell division. The resolution revolution in cryo-EM has enabled characterisation of the interaction of myosin with its actin track in several states of the myosin motor cycle, for multiple myosin classes, allowing increased insight into the force generation mechanism. A major advancement in our understanding of myosin-2 regulation has come through solving structures of its shutdown state, dysregulation of which is implicated in multiple diseases. This review will discuss what has been accomplished so far with cryoEM, what is still yet to do, but within reach, and how better understanding of myosin structure-function relationships may lead to future therapeutic interventions.
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Base de datos:
MEDLINE
Asunto principal:
Actinas
/
Miosinas
Idioma:
En
Revista:
Curr Opin Struct Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2022
Tipo del documento:
Article