Expression of a novel mycobacterial phosphodiesterase successfully lowers cAMP levels resulting in reduced tolerance to cell wall-targeting antimicrobials.

Thomson, Michael; Liu, Yi; Nunta, Kanokkan; Cheyne, Ashleigh; Fernandes, Nadia; Williams, Richard; Garza-Garcia, Acely; Larrouy-Maumus, Gerald

Thomson, Michael; Liu, Yi; Nunta, Kanokkan; Cheyne, Ashleigh; Fernandes, Nadia; Williams, Richard; Garza-Garcia, Acely; Larrouy-Maumus, Gerald.

Afiliación

Thomson M; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, United Kingdom.
Liu Y; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, United Kingdom.
Nunta K; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, United Kingdom.
Cheyne A; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, United Kingdom.
Fernandes N; Imperial BRC Genomics Facility, Imperial College London, London, United Kingdom.
Williams R; Imperial BRC Genomics Facility, Imperial College London, London, United Kingdom.
Garza-Garcia A; The Francis Crick Institute, London, United Kingdom.
Larrouy-Maumus G; MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, United Kingdom. Electronic address: g.larrouy-maumus@imperial.ac.uk.

J Biol Chem ; 298(8): 102151, 2022 08.

Article en En | MEDLINE | ID: mdl-35718063

Asunto(s)

Antiinfecciosos; Farmacorresistencia Bacteriana; Mycobacterium smegmatis; Hidrolasas Diéster Fosfóricas; Antiinfecciosos/farmacología; Proteínas Bacterianas/genética; Proteínas Bacterianas/metabolismo; Pared Celular/efectos de los fármacos; AMP Cíclico; Mycobacterium smegmatis/enzimología; Mycobacterium smegmatis/genética; Hidrolasas Diéster Fosfóricas/genética; Hidrolasas Diéster Fosfóricas/metabolismo

Palabras clave

3',5'-cAMP; antimicrobials tolerance; bioenergetics; mycobacteria; peptidoglycan; phosphodiesterases

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Hidrolasas Diéster Fosfóricas / Mycobacterium smegmatis / Farmacorresistencia Bacteriana / Antiinfecciosos Idioma: En Revista: J Biol Chem Año: 2022 Tipo del documento: Article

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