Cancer Stem Cells and Chemoresistance in Ewing Sarcoma.
Curr Stem Cell Res Ther
; 18(7): 926-936, 2023.
Article
en En
| MEDLINE
| ID: mdl-35761483
ABSTRACT
Resistance to chemotherapy poses a major challenge for cancer treatment. Reactivating a stem cell program resembling that seen in embryonic development can lead cancer cells to acquire a stem-cell phenotype characterized by expression of stemness genes, pluripotency, high self-renewal ability, and tumor-initiating capability. These cancer stem cells (CSCs) are usually resistant to anticancer drugs and are likely involved in treatment failure in many cancer types. Ewing sarcoma (ES) is a pediatric cancer type typically resulting from a typical genetic alteration affecting bone or soft tissues. Despite advances in treatment, survival prognostic remains poor for patients with refractory or recurrent disease. Here, we review the increasing evidence indicating that ES tumors contain a CSC subpopulation expressing stem cell genes, including BM1, OCT3/4, NANOG, and SOX2, that plays a role in resistance to drug treatment, and current experimental strategies that successfully counteract chemoresistance mediated by CSCs in ES.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sarcoma de Ewing
/
Antineoplásicos
Idioma:
En
Revista:
Curr Stem Cell Res Ther
Asunto de la revista:
TERAPEUTICA
Año:
2023
Tipo del documento:
Article