Degradable Polyampholytes from Radical Ring-Opening Copolymerization Enhance Cellular Cryopreservation.
ACS Macro Lett
; 11(7): 889-894, 2022 07 19.
Article
en En
| MEDLINE
| ID: mdl-35766585
ABSTRACT
Macromolecular cryoprotectants based on polyampholytes are showing promise as supplemental cryoprotectants alongside conventional DMSO-based freezing. Here we exploit radical ring-opening (ter)polymerization to access ester-containing cryoprotective polyampholytes, which were shown to be degradable. Using a challenging cell monolayer cryopreservation model, the degradable polyampholytes were found to enhance post-thaw recovery when supplemented into DMSO. This demonstrates that degradable macromolecular cryoprotectants can be developed for application in biotechnology and biomedicine.
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MEDLINE
Asunto principal:
Criopreservación
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Dimetilsulfóxido
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En
Revista:
ACS Macro Lett
Año:
2022
Tipo del documento:
Article