Combining PARP inhibition and immune checkpoint blockade in ovarian cancer patients: a new perspective on the horizon?
ESMO Open
; 7(4): 100536, 2022 08.
Article
en En
| MEDLINE
| ID: mdl-35849879
ABSTRACT
Immune checkpoint inhibitors (ICIs) have completely reshaped the treatment of many malignancies, with remarkable improvements in survival outcomes. In ovarian cancer (OC), however, this emerging class of drugs has not yet found a favorable use due to results from phase I and II studies, which have not suggested a substantial antitumoral activity of these agents when administered as monotherapy. Robust preclinical data seem to suggest that the combination ICIs with poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) may result in a synergistic activity; furthermore, data from phase II clinical studies, evaluating this combination, have shown encouraging outcomes especially for those OC patients not suitable for platinum retreatment. While waiting for ongoing phase III clinical trial results, which will clarify the role of ICIs in combination with PARPis in the newly diagnosed OC, this review aims to summarize the preclinical data and clinical evidence available to date.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Inhibidores de Poli(ADP-Ribosa) Polimerasas
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
ESMO Open
Año:
2022
Tipo del documento:
Article