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TCR-Vγδ usage distinguishes protumor from antitumor intestinal γδ T cell subsets.
Reis, Bernardo S; Darcy, Patrick W; Khan, Iasha Z; Moon, Christine S; Kornberg, Adam E; Schneider, Vanessa S; Alvarez, Yelina; Eleso, Olawale; Zhu, Caixia; Schernthanner, Marina; Lockhart, Ainsley; Reed, Aubrey; Bortolatto, Juliana; Castro, Tiago B R; Bilate, Angelina M; Grivennikov, Sergei; Han, Arnold S; Mucida, Daniel.
Afiliación
  • Reis BS; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Darcy PW; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Khan IZ; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Moon CS; Department of Medicine, Division of Digestive and Liver Diseases, Columbia University, New York, NY 10032, USA.
  • Kornberg AE; Department of Medicine, Division of Digestive and Liver Diseases, Columbia University, New York, NY 10032, USA.
  • Schneider VS; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Alvarez Y; Department of Biochemistry and Molecular Biology, Federal University of Parana, Curitiba, PR, Brazil.
  • Eleso O; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Zhu C; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Schernthanner M; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Lockhart A; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Reed A; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Bortolatto J; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Castro TBR; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Bilate AM; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Grivennikov S; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Han AS; Department of Medicine and Department of Biomedical Sciences, Cedars-Sinai Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Mucida D; Department of Medicine, Division of Digestive and Liver Diseases, Columbia University, New York, NY 10032, USA.
Science ; 377(6603): 276-284, 2022 07 15.
Article en En | MEDLINE | ID: mdl-35857588
γδ T cells represent a substantial fraction of intestinal lymphocytes at homeostasis, but they also constitute a major lymphocyte population infiltrating colorectal cancers (CRCs); however, their temporal contribution to CRC development or progression remains unclear. Using human CRC samples and murine CRC models, we found that most γδ T cells in premalignant or nontumor colons exhibit cytotoxic markers, whereas tumor-infiltrating γδ T cells express a protumorigenic profile. These contrasting T cell profiles were associated with distinct T cell receptor (TCR)-Vγδ gene usage in both humans and mice. Longitudinal intersectional genetics and antibody-dependent strategies targeting murine γδ T cells enriched in the epithelium at steady state led to heightened tumor development, whereas targeting γδ subsets that accumulate during CRC resulted in reduced tumor growth. Our results uncover temporal pro- and antitumor roles for γδ T cell subsets.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Receptores de Antígenos de Linfocitos T gamma-delta / Citotoxicidad Inmunológica / Linfocitos Intraepiteliales / Intestinos Idioma: En Revista: Science Año: 2022 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Receptores de Antígenos de Linfocitos T gamma-delta / Citotoxicidad Inmunológica / Linfocitos Intraepiteliales / Intestinos Idioma: En Revista: Science Año: 2022 Tipo del documento: Article