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Pseudoephedrine hydrochloride causes hyperactivity in zebrafish via modulation of the serotonin pathway.
Zhou, Yini; Li, Tonglaga; Zhou, Shangzi; Xu, Han; Yin, Xiaoyu; Chen, Hao; Ni, Xuan; Bai, Meirong; Ao, Wuliji; Yang, Jingfeng; Ahmed, R G; Zhang, Xuefu; Bao, Shuyin; Yu, Jianhua; Kwok, Kevin W H; Dong, Wu.
Afiliación
  • Zhou Y; Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
  • Li T; Affiliated Hospital of Inner Mongolia Minzu University, 028000, Tongliao, China.
  • Zhou S; Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
  • Xu H; Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
  • Yin X; Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
  • Chen H; Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
  • Ni X; Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
  • Bai M; College of Mongolian Medicine and Pharmacy, Inner Mongolia Minzu University, 028000, Tongliao, China.
  • Ao W; College of Mongolian Medicine and Pharmacy, Inner Mongolia Minzu University, 028000, Tongliao, China.
  • Yang J; Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
  • Ahmed RG; Division of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
  • Zhang X; The Medical College of Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
  • Bao S; The Medical College of Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China.
  • Yu J; Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and Technology, Inner Mongolia Minzu University, 028000, Tongliao, Inner Mongolia, China. yjhyjh926@163.com.
  • Kwok KWH; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong. kwh.kwok@polyu.edu.hk.
  • Dong W; Research Institute for Future Food, The Hong Kong Polytechnic University, Hung Hom, Hong Kong. kwh.kwok@polyu.edu.hk.
Metab Brain Dis ; 37(7): 2559-2568, 2022 10.
Article en En | MEDLINE | ID: mdl-35907131
This study aimed to explore behavioral changes of embryonic and larval zebrafish caused by pseudoephedrine hydrochloride (PSE) and its underlying mechanism. Zebrafish embryos were exposed to 0.5 µM, 2 µM, and 8 µM PSE at 4 h post-fertilization (4 hpf) or 22-23 hpf. Mortality, hatching rate, coiling frequency, heart rate, behavior changes, and related gene expression were observed at different developmental stages. PSE below 8 µM did not affect zebrafish mortality, hatching rate, and heart rate compared with the control group. For embryos, PSE caused an increase at 16-32 hpf in zebrafish coiling frequency which could be rescued by serotonin antagonist WAY100635. Similarly, PSE caused an increase in the swimming distance of zebrafish larvae at 120 hpf. PSE also elevated the expression of serotonin (5-HT)-related genes 5-htr1ab and tph2 and dopamine-related gene dbh. Behavioral changes in zebrafish embryos and larvae caused by PSE may be closely associated with increased expression of 5-HT and dopamine-related genes. This may be reflected that the behavioral changes in zebrafish are a possible PSE monitoring indicator.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pez Cebra / Embrión no Mamífero Tipo de estudio: Etiology_studies Idioma: En Revista: Metab Brain Dis Asunto de la revista: CEREBRO / METABOLISMO Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pez Cebra / Embrión no Mamífero Tipo de estudio: Etiology_studies Idioma: En Revista: Metab Brain Dis Asunto de la revista: CEREBRO / METABOLISMO Año: 2022 Tipo del documento: Article