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Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypes.
Deng, Ning; Wu, Yun-Yun; Feng, Yanan; Hsieh, Wen-Chieh; Song, Jen-Shin; Lin, Yu-Shiuan; Tseng, Ya-Hsien; Liao, Wan-Jhu; Chu, Yi-Fan; Liu, Yu-Cheng; Chang, En-Cheng; Liu, Chia-Rung; Sheu, Sheh-Yi; Su, Ming-Tsan; Kuo, Hung-Chih; Cohen, Stanley N; Cheng, Tzu-Hao.
Afiliación
  • Deng N; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
  • Wu YY; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, 11529, Taiwan.
  • Feng Y; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
  • Hsieh WC; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
  • Song JS; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
  • Lin YS; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan, 35053, Taiwan.
  • Tseng YH; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
  • Liao WJ; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
  • Chu YF; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
  • Liu YC; Department of Life Science and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
  • Chang EC; Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
  • Liu CR; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
  • Sheu SY; Institute of Biochemistry and Molecular Biology, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
  • Su MT; Department of Life Science and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan.
  • Kuo HC; Department of Life Science, National Taiwan Normal University, Taipei, 11677, Taiwan.
  • Cohen SN; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan.
  • Cheng TH; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305.
Proc Natl Acad Sci U S A ; 119(32): e2204779119, 2022 08 09.
Article en En | MEDLINE | ID: mdl-35914128
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fenotipo / Proteínas Represoras / Azauridina / Proteínas Nucleares / Enfermedad de Huntington / Factores de Elongación Transcripcional / Proteínas Mutantes / Proteína Huntingtina / Mutación Tipo de estudio: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fenotipo / Proteínas Represoras / Azauridina / Proteínas Nucleares / Enfermedad de Huntington / Factores de Elongación Transcripcional / Proteínas Mutantes / Proteína Huntingtina / Mutación Tipo de estudio: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article