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Glutamine metabolism modulates chondrocyte inflammatory response.
Arra, Manoj; Swarnkar, Gaurav; Adapala, Naga Suresh; Naqvi, Syeda Kanwal; Cai, Lei; Rai, Muhammad Farooq; Singamaneni, Srikanth; Mbalaviele, Gabriel; Brophy, Robert; Abu-Amer, Yousef.
Afiliación
  • Arra M; Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, United States.
  • Swarnkar G; Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, United States.
  • Adapala NS; Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, United States.
  • Naqvi SK; Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, United States.
  • Cai L; Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, United States.
  • Rai MF; Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, United States.
  • Singamaneni S; Department of Mechanical Engineering and Material Sciences, Washington University School of Medicine, St Louis, United States.
  • Mbalaviele G; Bone and Mineral Division, Department of Medicine, Washington University School of Medicine, St Louis, United States.
  • Brophy R; Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, United States.
  • Abu-Amer Y; Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, United States.
Elife ; 112022 08 02.
Article en En | MEDLINE | ID: mdl-35916374
Osteoarthritis is the most common joint disease in the world with significant societal consequences but lacks effective disease-modifying interventions. The pathophysiology consists of a prominent inflammatory component that can be targeted to prevent cartilage degradation and structural defects. Intracellular metabolism has emerged as a culprit of the inflammatory response in chondrocytes, with both processes co-regulating each other. The role of glutamine metabolism in chondrocytes, especially in the context of inflammation, lacks a thorough understanding and is the focus of this work. We display that mouse chondrocytes utilize glutamine for energy production and anabolic processes. Furthermore, we show that glutamine deprivation itself causes metabolic reprogramming and decreases the inflammatory response of chondrocytes through inhibition of NF-κB activity. Finally, we display that glutamine deprivation promotes autophagy and that ammonia is an inhibitor of autophagy. Overall, we identify a relationship between glutamine metabolism and inflammatory signaling and display the need for increased study of chondrocyte metabolic systems.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Osteoartritis / Condrocitos Tipo de estudio: Prognostic_studies Idioma: En Revista: Elife Año: 2022 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Osteoartritis / Condrocitos Tipo de estudio: Prognostic_studies Idioma: En Revista: Elife Año: 2022 Tipo del documento: Article