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In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes.
Ribeiro, Silviana; Sousa, Mário.
Afiliación
  • Ribeiro S; Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal.
  • Sousa M; Unit for Multidisciplinary Research in Biomedicine (UMIB)/Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal.
JBRA Assist Reprod ; 27(1): 97-111, 2023 03 30.
Article en En | MEDLINE | ID: mdl-35916467
The development of assisted reproductive technology has allowed offspring in infertile couples, and specifically, allowed infertile men to conceive through Intracytoplasmic Sperm Injection (ICSI). Despite the proven efficacy of In Vitro Fertilisation (IVF) and ICSI, many factors can influence its success. In this review we present an analysis on the effect of Female age, Ovarian Reserve, Male age and Male factor on the outcomes of IVF/ICSI, to determine if and which can be applied to the practical context. A literature search on PubMed, EMBASE and MEDLINE for relevant articles was elaborated until July 2021, leading to the selection of 234 articles based on their titles. After reading through the abstracts, those that evaluated IVF/ICSI predicting factors were selected. Finally, only those approaching female age, ovarian reserve, male age and male factor were considered in this review. Higher female age and baseline ovarian markers alterations such as lower anti-Müllerian hormone and antral follicular count, and higher basal follicle-stimulating hormone, were associated with poorer outcomes. The predictive value of Male age and Male factor presented varied results across literature. The multifactorial nature of male fertility makes evaluation difficult. Although the first assessment of male infertility is based on sperm concentration, motility and morphology, semen parameters have shown low prognostic value, whilst sperm DNA alterations gain importance. Nevertheless, results remain controversial. While some factors have proven to predict IVF/ICSI success, other need to be further studied to be applied to practical context to allow the best prognosis possible.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Inyecciones de Esperma Intracitoplasmáticas / Reserva Ovárica Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: JBRA Assist Reprod Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Inyecciones de Esperma Intracitoplasmáticas / Reserva Ovárica Tipo de estudio: Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: JBRA Assist Reprod Año: 2023 Tipo del documento: Article