A fast gas chromatography coupled with electron capture negative ion mass spectrometry in selected ion monitoring mode screening method for short-chain and medium-chain chlorinated paraffins.
Rapid Commun Mass Spectrom
; 36(22): e9382, 2022 Nov 30.
Article
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| MEDLINE
| ID: mdl-36001505
ABSTRACT
RATIONALE Chlorinated paraffins (CPs) are a group of anthropogenic pollutants that consist of complex mixtures of polychlorinated n-alkanes of different chain lengths (~C10 to C30 ). Persistence, bioaccumulation, toxicity, and long-range transport of short-chain chlorinated paraffins (SCCPs, C10 - to C13 -CPs) have prompted their classification as persistent organic pollutants (POPs) by the Stockholm Convention in 2017. Due to the varying chain lengths and chlorination degrees, quantification of SCCPs and medium-chain chlorinated paraffins (MCCPs, C14 - to C17 ) using gas chromatography coupled with electron capture negative ion mass spectrometry in selected ion monitoring mode (GC/ECNI-MS-SIM) is not only challenging but also very time consuming. In particular, up to eight GC runs per sample are required for the comprehensive GC/ECNI-MS-SIM quantification of SCCPs and MCCPs. These efforts are high especially if the samples do not contain CPs above the limit of detection (LOD), subsequently. METHODS:
We developed a semi-quantitative and sensitive method for the examination of SCCPs and MCCPs in one GC run. This GC/ECNI-MS-SIM screening method was based on the recording of Cl- (m/z 35 and 37), Cl2 - (m/z 70 and 72), and HCl2 - (m/z 71 and 73) isotope ions and evaluation of the ratios between them.RESULTS:
Correctness of the results of the screening method was verified by analysis of edible oils with and without CPs, CP standards, as well as a technical CP mixture. Polychlorinated biphenyls (PCBs) and other polyhalogenated aromatic compounds, as well as brominated flame retardants, do not form all of the fragment ions analyzed by the screening method.CONCLUSIONS:
After the screening, only CP-positive samples may need to be measured in detail. Measurement time will already be gained in the case of ~10% samples without CPs.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Bifenilos Policlorados
/
Contaminantes Ambientales
/
Retardadores de Llama
/
Hidrocarburos Clorados
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
Rapid Commun Mass Spectrom
Año:
2022
Tipo del documento:
Article