Fetal sex-specific epigenetic associations with prenatal maternal depressive symptoms.
iScience
; 25(9): 104860, 2022 Sep 16.
Article
en En
| MEDLINE
| ID: mdl-36046194
Prenatal maternal mental health is a global health challenge with poorly defined biological mechanisms. We used maternal blood samples collected during the second trimester from a Singaporean longitudinal birth cohort study to examine the association between inter-individual genome-wide DNA methylation and prenatal maternal depressive symptoms. We found that (1) the maternal methylome was significantly associated with prenatal maternal depressive symptoms only in mothers with a female fetus; and (2) this sex-dependent association was observed in a comparable, UK-based birth cohort study. Qualitative analyses showed fetal sex-specific differences in genomic features of depression-related CpGs and genes mapped from these CpGs in mothers with female fetuses implicated in a depression-associated WNT/ß-catenin signaling pathway. These same genes also showed enriched expression in brain regions linked to major depressive disorder. We also found similar female-specific associations with fetal-facing placenta methylome. Our fetal sex-specific findings provide evidence for maternal-fetal interactions as a mechanism for intergenerational transmission.
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Base de datos:
MEDLINE
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Qualitative_research
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Risk_factors_studies
Idioma:
En
Revista:
IScience
Año:
2022
Tipo del documento:
Article