Parkin Insufficiency Accentuates High-Fat Diet-Induced Cardiac Remodeling and Contractile Dysfunction Through VDAC1-Mediated Mitochondrial Ca2+ Overload.
JACC Basic Transl Sci
; 7(8): 779-796, 2022 Aug.
Article
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| MEDLINE
| ID: mdl-36061337
AMCM, adult murine cardiomyocyte; BP, blood pressure; Ca2+ overload; HFD, high-fat diet; LFD, low-fat diet; LV, left ventricular; MCU, mitochondrial Ca2+ uniporter; PA, palmitic acid; Parkin; ROS, reactive oxygen species; TR90, time to 90% relengthening; VDAC, voltage-dependent anion channel; VDAC1; WT, wild-type; heart; high-fat diet; mPTP, mitochondrial permeability transition pore; mitochondria
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JACC Basic Transl Sci
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