Targeting Lineage-Specific Transcription Factors and Cytokines of the Th17/Treg Axis by Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-<i>d</i>]pyridazinone Attenuates TNBS-Induced Experimental Colitis.

Szandruk-Bender, Marta; Wiatrak, Benita; Dzimira, Stanislaw; Merwid-Lad, Anna; Szczukowski, Lukasz; Swiatek, Piotr; Szelag, Adam

Targeting Lineage-Specific Transcription Factors and Cytokines of the Th17/Treg Axis by Novel 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Attenuates TNBS-Induced Experimental Colitis.

Szandruk-Bender, Marta; Wiatrak, Benita; Dzimira, Stanislaw; Merwid-Lad, Anna; Szczukowski, Lukasz; Swiatek, Piotr; Szelag, Adam.

Afiliación

Szandruk-Bender M; Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.
Wiatrak B; Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.
Dzimira S; Department of Pathology, Wroclaw University of Environmental and Life Sciences, Norwida 31, 50-375 Wroclaw, Poland.
Merwid-Lad A; Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.
Szczukowski L; Department of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Swiatek P; Department of Medicinal Chemistry, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Szelag A; Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.

Int J Mol Sci ; 23(17)2022 Aug 31.

Article en En | MEDLINE | ID: mdl-36077306

Asunto(s)

Colitis; Enfermedades Inflamatorias del Intestino; Animales; Colitis/inducido químicamente; Colitis/tratamiento farmacológico; Colitis/metabolismo; Citocinas/metabolismo; Modelos Animales de Enfermedad; Enfermedades Inflamatorias del Intestino/tratamiento farmacológico; Interleucina-17/metabolismo; Interleucina-23/metabolismo; Interleucina-6/metabolismo; Miembro 3 del Grupo F de la Subfamilia 1 de Receptores Nucleares/metabolismo; Oxadiazoles; Prostaglandinas E/efectos adversos; Ratas; Factor de Transcripción STAT3/metabolismo; Linfocitos T Reguladores/metabolismo; Células Th17/metabolismo; Ácido Trinitrobencenosulfónico/efectos adversos; Factor de Necrosis Tumoral alfa/metabolismo

Palabras clave

Foxp3; IL-23; IL-6; RORÎ³t; Th17/Treg axis; experimental colitis; inflammatory bowel disease; inflammatory mediators; pyrrolo[3,4-d]pyridazinone; trinitrobenzenesulfonic acid

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Colitis Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article

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