SH-PRO extract alleviates benign prostatic hyperplasia via ROS-mediated activation of PARP/caspase 3 and inhibition of FOXO3a/AR/PSA signaling in vitro and in vivo.

Park, Ji Eon; Shin, Woo-Cheol; Lee, Hyo-Jung; Yoon, Dahye; Sim, Deok Yong; Ahn, Chi-Hoon; Park, Su-Yeon; Shim, Bum Sang; Park, So Jung; Kim, Kyung Seok; Park, Geum Duck; Kim, Sung-Hoon; Lee, Dae Young

Park, Ji Eon; Shin, Woo-Cheol; Lee, Hyo-Jung; Yoon, Dahye; Sim, Deok Yong; Ahn, Chi-Hoon; Park, Su-Yeon; Shim, Bum Sang; Park, So Jung; Kim, Kyung Seok; Park, Geum Duck; Kim, Sung-Hoon; Lee, Dae Young.

Afiliación

Park JE; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Shin WC; Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong, Republic of Korea.
Lee HJ; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Yoon D; Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong, Republic of Korea.
Sim DY; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Ahn CH; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Park SY; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Shim BS; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Park SJ; Suheung Research Center, Seongnam, Republic of Korea.
Kim KS; Suheung Research Center, Seongnam, Republic of Korea.
Park GD; Suheung Research Center, Seongnam, Republic of Korea.
Kim SH; College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Lee DY; Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong, Republic of Korea.

Phytother Res ; 37(2): 452-463, 2023 Feb.

Article en En | MEDLINE | ID: mdl-36122906

Asunto(s)

Hiperplasia Prostática; Masculino; Humanos; Ratas; Animales; Hiperplasia Prostática/tratamiento farmacológico; Hiperplasia Prostática/inducido químicamente; Antígeno Prostático Específico; Especies Reactivas de Oxígeno/efectos adversos; Inhibidores de Poli(ADP-Ribosa) Polimerasas/uso terapéutico; Receptores Androgénicos/metabolismo; Caspasas; Caspasa 3; Extractos Vegetales/uso terapéutico; Testosterona/efectos adversos

Palabras clave

FOXO3a; ROS; SH-PRO; apoptosis; benign ptatic hyperplasia; ros

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Hiperplasia Prostática Idioma: En Revista: Phytother Res Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2023 Tipo del documento: Article

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