Stem Cell Therapy for Sequestration of Traumatic Brain Injury-Induced Inflammation.
Int J Mol Sci
; 23(18)2022 Sep 07.
Article
en En
| MEDLINE
| ID: mdl-36142198
ABSTRACT
Traumatic brain injury (TBI) is one of the leading causes of long-term neurological disabilities in the world. TBI is a signature disease for soldiers and veterans, but also affects civilians, including adults and children. Following TBI, the brain resident and immune cells turn into a "reactive" state, characterized by the production of inflammatory mediators that contribute to the development of cognitive deficits. Other injuries to the brain, including radiation exposure, may trigger TBI-like pathology, characterized by inflammation. Currently there are no treatments to prevent or reverse the deleterious consequences of brain trauma. The recognition that TBI predisposes stem cell alterations suggests that stem cell-based therapies stand as a potential treatment for TBI. Here, we discuss the inflamed brain after TBI and radiation injury. We further review the status of stem cells in the inflamed brain and the applications of cell therapy in sequestering inflammation in TBI.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Trastornos del Conocimiento
/
Lesiones Traumáticas del Encéfalo
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Int J Mol Sci
Año:
2022
Tipo del documento:
Article