Alkyl-substituted N-methylaryl-N'-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase.

Robello, Marco; Zheng, Hongchao; Saha, Mrinmoy; George Rosenker, Kara M; Debnath, Subrata; Kumar, Jay Prakash; Tagad, Harichandra D; Mazur, Sharlyn J; Appella, Ettore; Appella, Daniel H

Robello, Marco; Zheng, Hongchao; Saha, Mrinmoy; George Rosenker, Kara M; Debnath, Subrata; Kumar, Jay Prakash; Tagad, Harichandra D; Mazur, Sharlyn J; Appella, Ettore; Appella, Daniel H.

Afiliación

Robello M; Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, United States.
Zheng H; Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, United States.
Saha M; Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, United States.
George Rosenker KM; Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, United States.
Debnath S; Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, MD, 20892, United States.
Kumar JP; Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, MD, 20892, United States.
Tagad HD; Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, MD, 20892, United States.
Mazur SJ; Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, MD, 20892, United States.
Appella E; Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, MD, 20892, United States.
Appella DH; Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, United States. Electronic address: appellad@niddk.nih.gov.

Eur J Med Chem ; 243: 114763, 2022 Dec 05.

Article en En | MEDLINE | ID: mdl-36179402

Asunto(s)

Fosfoproteínas Fosfatasas; Proteína p53 Supresora de Tumor; Humanos; Proteína Fosfatasa 2C/genética; Proteína Fosfatasa 2C/metabolismo; Fosfoproteínas Fosfatasas/genética; Fosfoproteínas Fosfatasas/metabolismo; Proteína p53 Supresora de Tumor/metabolismo; Proteínas Serina-Treonina Quinasas; Daño del ADN; Fosforilación

Palabras clave

Aminobenzamides; Cancer treatment; Cross coupling; Phosphate; Small molecule inhibitors; Wip1 phosphatase

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor / Fosfoproteínas Fosfatasas Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article

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