Impact of pregnancy related hormones on drug metabolizing enzyme and transport protein concentrations in human hepatocytes.

Fashe, Muluneh M; Fallon, John K; Miner, Taryn A; Tiley, Jacqueline B; Smith, Philip C; Lee, Craig R

Fashe, Muluneh M; Fallon, John K; Miner, Taryn A; Tiley, Jacqueline B; Smith, Philip C; Lee, Craig R.

Afiliación

Fashe MM; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Fallon JK; Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Miner TA; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Tiley JB; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Smith PC; Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Lee CR; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Front Pharmacol ; 13: 1004010, 2022.

Article en En | MEDLINE | ID: mdl-36210832

Palabras clave

carboxylesterase; drug transporters; flavin monooxygenase; hepatic drug disposition; pregnanacy; pregnancy hormones; targeted proteomics; uridine diphosphate glucuronosyltransferases (UGTs)

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