Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis <i>via</i> the inhibition of the SIRT3/SMCT1 pathway.

Xie, Jinlan; Zhong, Feifei; Guo, Zhenhong; Li, Xinran; Wang, Jingyu; Gao, Zhongai; Chang, Baocheng; Yang, Juhong

Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway.

Xie, Jinlan; Zhong, Feifei; Guo, Zhenhong; Li, Xinran; Wang, Jingyu; Gao, Zhongai; Chang, Baocheng; Yang, Juhong.

Afiliación

Xie J; Department of Endocrinology, National Health Commission Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases, Endocrinology Institute of Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Zhong F; Department of Endocrinology, National Health Commission Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases, Endocrinology Institute of Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Guo Z; Department of Endocrinology, National Health Commission Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases, Endocrinology Institute of Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Li X; Department of Endocrinology, National Health Commission Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases, Endocrinology Institute of Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Wang J; Department of Endocrinology, National Health Commission Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases, Endocrinology Institute of Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Gao Z; Department of Endocrinology, National Health Commission Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases, Endocrinology Institute of Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Chang B; Department of Endocrinology, National Health Commission Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases, Endocrinology Institute of Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Yang J; Department of Endocrinology, National Health Commission Key Laboratory of Hormones and Development Tianjin Key Laboratory of Metabolic Diseases, Endocrinology Institute of Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

Front Endocrinol (Lausanne) ; 13: 960835, 2022.

Article en En | MEDLINE | ID: mdl-36237185

Asunto(s)

Hiperinsulinismo; Sirtuina 3; Inanición; Ácido 3-Hidroxibutírico; Adenosina Trifosfato; Albúminas/metabolismo; Animales; Células Epiteliales/metabolismo; Glucosa/metabolismo; Hexosaminidasas/metabolismo; Insulina/metabolismo; Cuerpos Cetónicos; Ratones; Ratones Noqueados; Ratas; Proteínas de Unión al Retinol; Sirtuina 3/metabolismo; Transferrinas

Palabras clave

Hyperinsulinemia; metabolic flexibility; mitochondria; proximal tubular epithelial cells; ß-hydroxybutyrate

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Inanición / Sirtuina 3 / Hiperinsulinismo Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2022 Tipo del documento: Article

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