NR4A1 modulates intestinal smooth muscle cell phenotype and dampens inflammation-associated intestinal remodeling.

Szczepanski, Holly E; Flannigan, Kyle L; Mainoli, Barbara; Alston, Laurie; Baruta, Grace M; Lee, Joshua W; Venu, Vivek Krishna Pulakazhi; Shearer, Jane; Dufour, Antoine; Hirota, Simon A

Szczepanski, Holly E; Flannigan, Kyle L; Mainoli, Barbara; Alston, Laurie; Baruta, Grace M; Lee, Joshua W; Venu, Vivek Krishna Pulakazhi; Shearer, Jane; Dufour, Antoine; Hirota, Simon A.

Afiliación

Szczepanski HE; Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada.
Flannigan KL; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
Mainoli B; Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada.
Alston L; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
Baruta GM; Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada.
Lee JW; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
Venu VKP; Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada.
Shearer J; Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada.
Dufour A; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
Hirota SA; Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada.

FASEB J ; 36(11): e22609, 2022 11.

Article en En | MEDLINE | ID: mdl-36250380

Asunto(s)

Enfermedad de Crohn; Mercaptopurina; Animales; Células Cultivadas; Constricción Patológica/complicaciones; Constricción Patológica/metabolismo; Enfermedad de Crohn/metabolismo; Sulfato de Dextran; Inflamación/metabolismo; Mercaptopurina/metabolismo; Ratones; Músculo Liso; Miocitos del Músculo Liso/metabolismo; Miembro 1 del Grupo A de la Subfamilia 4 de Receptores Nucleares/genética; Miembro 1 del Grupo A de la Subfamilia 4 de Receptores Nucleares/metabolismo; Receptores Nucleares Huérfanos/metabolismo; Fenotipo; Fenilacetatos; Proteómica

Palabras clave

Crohn's disease; NR4A1; fibrostenosis; inflammation; smooth muscle

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Crohn / Mercaptopurina Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2022 Tipo del documento: Article

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