Association of intron 4 VNTR polymorphism in the NOS3 gene with rapid cycling and treatment resistance in bipolar disorder: a case-control study.
Neurosciences (Riyadh)
; 27(4): 229-236, 2022 Oct.
Article
en En
| MEDLINE
| ID: mdl-36252968
ABSTRACT
OBJECTIVE:
To evaluate the relationship between patients' clinical parameters, especially clinical specifiers, and the intron 4 VNTR variant of the endothelial nitric oxide synthase (NOS3) gene in bipolar disorder (BD) patients.METHODS:
A sample of 95 patients with BD and 95 healthy volunteers were included in the case-control study. The patients consecutively admitted to the outpatient psychiatry clinic for 6 months and were evaluated with some scales for clinical parameters. In addition, PCR was used to determine the NOS3 intron 4 VNTR variant.RESULTS:
The NOS3 genotype and allele frequency distributions of rapid cycling BD patients were significantly different from non-rapid cycling BD patients and the control groups. Furthermore, NOS3 genotype and allele frequency distributions of treatment-resistant BD patients were significantly different from treatment-responsive BD patients and the control groups. While BD patients carrying the b/b genotype and b allele had a lower risk of rapid cycling and treatment resistance, having the b/a genotype in BD patients was at higher risk in terms of rapid cycling and treatment resistance. In addition, the number of hospitalizations and the Clinical Global Impression-Improvement Scale scores of the BD group with the b/b genotype were statistically lower than the BD group with b/a and a/a genotypes.CONCLUSIONS:
We propose that the intron 4 VNTR variant of the NOS3 gene may be associated with rapid cycling and treatment resistance in Turkish patients diagnosed with BD.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Trastorno Bipolar
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Neurosciences (Riyadh)
Asunto de la revista:
NEUROLOGIA
Año:
2022
Tipo del documento:
Article