Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone.
World Allergy Organ J
; 15(10): 100705, 2022 Oct.
Article
en En
| MEDLINE
| ID: mdl-36267098
ABSTRACT
Background:
Population and study's methodology heterogenicity became clinical evolution of chronic spontaneous urticaria (CSU) highly variable.Objective:
In a prospective cohort, we evaluated the different pathways of clinical evolution of CSU and identified possible risk factors.Methods:
A total of 685 CSU patients (>12 years) were prospectively followed over 5 years. Diagnosis and follow-up of urticaria were based on medical evaluation and photographic records. Remission was defined as at least 6 months without symptoms (hives, angioedema, or pruritus) and medication. The follow-up included at least 2 visits per year, with photographic registration and clinical evaluation. Predefined clinical and paraclinical variables were included in the regression analyses.Results:
We identified four clinical evolution pathways; The cumulative prevalence of remission at 5 years was 59.1%, recurrence was 17.1%, persistence was 11.6%, and chronic pruritus without hives or angioedema was 12.2%. The probability of persistence increased with hypothyroidism diagnosis (HR 0.425, 95% CI 0.290-0.621) and each point in the UAS7 (HR 0.931 95% CI 0.918-0.945).Conclusion:
Chronic urticaria has different evolutions. Disease activity and hypothyroidism predict persistence and remission. Recurrence and chronic pruritus phenotypes require further study to evaluate their causality and prognosis.
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Base de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
World Allergy Organ J
Año:
2022
Tipo del documento:
Article