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Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.
Okombo, John; Mok, Sachel; Qahash, Tarrick; Yeo, Tomas; Bath, Jade; Orchard, Lindsey M; Owens, Edward; Koo, Imhoi; Albert, Istvan; Llinás, Manuel; Fidock, David A.
Afiliación
  • Okombo J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America.
  • Mok S; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America.
  • Qahash T; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, United States of America.
  • Yeo T; Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
  • Bath J; Huck Center for Malaria Research, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
  • Orchard LM; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America.
  • Owens E; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America.
  • Koo I; Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
  • Albert I; Huck Center for Malaria Research, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
  • Llinás M; Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
  • Fidock DA; Huck Center for Malaria Research, The Pennsylvania State University, University Park, Pennsylvania, United States of America.
PLoS Pathog ; 18(10): e1010926, 2022 10.
Article en En | MEDLINE | ID: mdl-36306287
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Parásitos / Malaria Falciparum / Artemisininas / Antimaláricos Idioma: En Revista: PLoS Pathog Año: 2022 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Parásitos / Malaria Falciparum / Artemisininas / Antimaláricos Idioma: En Revista: PLoS Pathog Año: 2022 Tipo del documento: Article