Your browser doesn't support javascript.
loading
The induction of ferroptosis in posthemorrhagic hydrocephalus.
Meng, Zilin; Liu, Chunbo; Chen, Chao; Di, Fanglin; Zhang, Shuping; Liang, Xue; Li, Meng.
Afiliación
  • Meng Z; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University, Jinan, Shandong 250117, China.
  • Liu C; Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China.
  • Chen C; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University, Jinan, Shandong 250117, China.
  • Di F; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University, Jinan, Shandong 250117, China.
  • Zhang S; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University, Jinan, Shandong 250117, China; Medical Science and Technology Innovation Center, Shandong First Medical University, Jinan, Shandong 250117, China.
  • Liang X; School of Public Health, Shandong First Medical University, Jinan, Shandong 250117, China; Medical Science and Technology Innovation Center, Shandong First Medical University, Jinan, Shandong 250117, China. Electronic address: liangxue@sdfmu.edu.cn.
  • Li M; Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China. Electronic address: drlimeng@126.com.
Brain Res ; 1798: 148133, 2023 01 01.
Article en En | MEDLINE | ID: mdl-36341902
Posthemorrhagic hydrocephalus (PHH) is a common neurological disease characterized by the disordered secretion of cerebrospinal fluid from the choroid plexus, ventricular dilation, and increased intracranial pressure after hemorrhage. Although these pathological processes are well established, the effective biomarkers for the diagnosis of PHH are still limited, largely because the underlying mechanisms-including cell death in the choroid plexus-are not well defined. Ferroptosis, a newly recognized type of programmed cell death, has been found to play a key role in a variety of pathologic conditions and diseases, including Parkinson's and Alzheimer's diseases. However, whether ferroptosis is induced in PHH is still unknown. In the current study, a rat model of PHH was established to investigate the induction of ferroptosis in PHH. Along with defects in memory and cognition, we observed that rats with experimentally induced PHH also demonstrated lipid peroxidation (a key marker of ferroptosis), as well as a significant increase and a significant decrease in two ferroptosis-specific genes, ACSL4 and SLC7A11, respectively. Thus, ferroptosis may serve as an auxiliary indicator for the diagnosis of PHH.
Asunto(s)
Palabras clave

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ferroptosis / Hidrocefalia Idioma: En Revista: Brain Res Año: 2023 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ferroptosis / Hidrocefalia Idioma: En Revista: Brain Res Año: 2023 Tipo del documento: Article