Association of serum anion gap and risk of long-term mortality in patients following coronary artery bypass grafting: A propensity score matching study.
J Card Surg
; 37(12): 4906-4918, 2022 Dec.
Article
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| MEDLINE
| ID: mdl-36378900
ABSTRACT
BACKGROUND:
The present study aimed to explore the relationship between serum anion gap (AG) and long-term mortality in patients undergoing coronary artery bypass grafting (CABG).METHODS:
Clinical variables were extracted among patients undergoing CABG from Medical Information Mart for Intensive Care III (MIMIC III) database. The primary outcome was 4-year mortality following CABG. An optimal cut-off value of AG was determined by the receiver operating characteristic (ROC) curve. The Kaplan-Meier (K-M) analysis and multivariate Cox hazard analysis were performed to investigate the prognostic value of AG in long-term mortality after CABG. To eliminate the bias between different groups, propensity score matching (PSM) was conducted to validate the findings.RESULTS:
The optimal cut-off value of AG was 17.00 mmol/L. Then a total of 3162 eligible patients enrolled in this study were divided into a high AG group (≥17.00, n = 1022) and a low AG group (<17.00, n = 2,140). A lower survival rate was identified in the high AG group based on the K-M curve (p < .001). Compared with patients in the low AG group, patients in the high AG group had an increased risk of long-term mortality [1-year mortality hazard ratio, HR 2.309, 95% CI (1.672-3.187), p < .001; 2-year mortality HR 1.813, 95% CI (1.401-2.346), p < .001; 3- year mortality HR 1.667, 95% CI (1.341-2.097), p < .001; 4-year mortality HR 1.710, 95% CI (1.401-2.087), p < .001] according to multivariate Cox hazard analysis. And further validation of above results was consistent in the matched cohort after PSM.CONCLUSIONS:
The AG is an independent predictive factor for long-term all-cause mortality in patients following CABG, where a high AG value is associated with an increased mortality.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Equilibrio Ácido-Base
/
Enfermedad de la Arteria Coronaria
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Card Surg
Asunto de la revista:
CARDIOLOGIA
Año:
2022
Tipo del documento:
Article