Hepatitis B virus DNA methylation and its potential role in chronic hepatitis B.
Expert Rev Mol Med
; 25: e11, 2022 11 16.
Article
en En
| MEDLINE
| ID: mdl-36380484
ABSTRACT
Hepatitis B virus (HBV) infection led to 66% liver deaths world-wide in year 2015. Thirty-seven per cent of these deaths were the result of chronic hepatitis B (CHB)-associated hepatocellular carcinoma (HCC). Although early diagnosis of HCC improves survival, early detection is rare. Methylation of HBV DNA including covalently closed circular DNA (cccDNA) is more often encountered in HCC cases than those in CHB and cirrhosis. Three typical CpG islands within the HBV genome are the common sites for methylation. The HBV cccDNA methylation affects the viral replication and protein expression in the course of infection and may associate with the disease pathogenesis and HCC development. We review the current findings in HBV DNA methylation that provide insights into its role in HCC diagnosis.
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Base de datos:
MEDLINE
Asunto principal:
Carcinoma Hepatocelular
/
Hepatitis B Crónica
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Hepatitis B
/
Neoplasias Hepáticas
Idioma:
En
Revista:
Expert Rev Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2022
Tipo del documento:
Article