The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study.
Aging (Albany NY)
; 14(22): 8927-8943, 2022 11 17.
Article
en En
| MEDLINE
| ID: mdl-36399107
ABSTRACT
PURPOSE:
Metformin has been reported to improve age-related disorders, including dementia, and to lower mortality. This study was conducted to investigate whether metformin use lower delirium risk, as well as long-term mortality.METHODS:
In this retrospective cohort study, previously recruited 1,404 subjects were analyzed. The relationship between metformin use and delirium, and the relationship between metformin use and 3-year mortality were investigated. MAINFINDINGS:
242 subjects were categorized into a type 2 diabetes mellitus (DM)-without-metformin group, and 264 subjects were categorized into a DM-with-metformin group. Prevalence of delirium was 36.0% in the DM-without-metformin group, and 29.2% in the DM-with-metformin group. A history of metformin use reduced the risk of delirium in patients with DM (OR, 0.50 [95% CI, 0.32 to 0.79]) after controlling for confounding factors. The 3-year mortality in the DM-without-metformin group (survival rate, 0.595 [95% CI, 0.512 to 0.669]) was higher than in the DM-with-metformin group (survival rate, 0.695 [95% CI, 0.604 to 0.770]) (p=0.035). A history of metformin use decreased the risk of 3-year mortality after adjustment for confounding factors (HR, 0.69 [95% CI, 0.48 to 0.98]).CONCLUSIONS:
Metformin use may lower the risk of delirium and mortality in DM patients.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Delirio
/
Diabetes Mellitus Tipo 2
/
Metformina
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Aging (Albany NY)
Asunto de la revista:
GERIATRIA
Año:
2022
Tipo del documento:
Article